Eudrate

• Topical treatment of dry, rough, scaly, or hyperkeratotic skin conditions including:
• Xerosis (dry skin)
• Ichthyosis
• Psoriasis
• Eczema
• Keratoderma
• Softening and hydration of thickened skin, calluses, corns, and thickened nails
• Adjunctive therapy to enhance penetration of topical medications in dermatologic conditions

• Adults:
• Apply topically once or twice daily.
• Concentrations vary by indication: 5-10% for mild dryness; 20-40% for hyperkeratosis or thickened nails.
• Pediatrics:
• Use lower concentrations (≤10%) with caution; avoid on broken skin.
• Elderly:
• Same as adults; may require more frequent application due to skin dryness.
• Special Populations:
• Avoid application to open wounds or infected skin unless prescribed.
• Route:
• Topical (cream, ointment, lotion, solution)
• Duration:
• Continue as needed for symptom relief; long-term use may be necessary in chronic conditions.

Urea acts as a humectant and keratolytic agent. At low concentrations, it increases water content of the stratum corneum by attracting moisture. At higher concentrations, it breaks down keratin bonds in the skin, promoting exfoliation and softening of thickened skin.

• Minimal systemic absorption when applied to intact skin.
• Localized effect in epidermis; metabolized locally.
• Any absorbed urea is excreted renally.
• Onset: Hydrating effects within hours; keratolytic effects develop over days to weeks.

• No controlled studies in humans.
• Considered low risk due to minimal absorption.
• Use during pregnancy and lactation only if clearly needed.

• Dermatologic agent
• Keratolytic and humectant

• Hypersensitivity to urea or formulation components
• Application on infected, inflamed, or ulcerated skin without medical advice

• Avoid eye and mucous membrane contact.
• May cause mild irritation or burning; discontinue if severe.
• Use cautiously on sensitive or damaged skin.

• Common: Mild burning, stinging, redness
• Rare: Allergic contact dermatitis

• No significant known interactions
• May enhance penetration of concomitant topical drugs; monitor accordingly

• Endorsed as first-line moisturizing and keratolytic agent in dermatology guidelines
• Recognized for improving skin barrier and enhancing drug delivery
• No major recent changes in safety or dosing

• Store at 20–25°C (68–77°F) in a tightly closed container
• Protect from moisture, heat, and direct sunlight
• Keep out of reach of children