Yohimbine Hydrochloride
Herbal
Indications
Approved Indications
- Erectile Dysfunction (ED): Management of psychogenic and vasculogenic erectile dysfunction in men.
- Orthostatic Hypotension: Sometimes prescribed to prevent abnormally low blood pressure in certain patients.
Clinically Accepted Off-Label Uses
- Female Sexual Arousal Disorder: Studied for improving libido and arousal in women.
- Obesity & Weight Management: Investigated for fat metabolism and as an adjunct in weight reduction.
- Raynaud’s Syndrome: May improve peripheral circulation and reduce vasospasm.
Dosage & Administration
- Adults (ED): 5.4 mg to 10.8 mg daily in divided doses, usually before meals. Dose may be titrated as advised by physician.
- Orthostatic Hypotension: 5.4 mg three times daily.
- Maximum Daily Dose: Not more than 30 mg.
- Elderly/Renal Impairment: Begin with lowest possible dose; monitor closely.
- Pediatric Use: Not recommended.
Mechanism of Action (MOA)
Yohimbine is an alpha-2 adrenergic receptor antagonist. By blocking presynaptic alpha-2 receptors, it increases norepinephrine release, enhances sympathetic activity, and improves penile blood flow. This mechanism supports erection and increased libido.
Pregnancy & Lactation
- Pregnancy: Contraindicated; safety not established.
- Lactation: Avoid; insufficient data on excretion in breast milk.
Storage Conditions
- Store below 25°C in a cool, dry place.
- Protect from light and moisture.