Tea tree oil + Echinacea + Geothermal water

Approved & Clinically Accepted Uses:

• Acne vulgaris – Mild to moderate inflammatory and non-inflammatory lesions
• Seborrheic dermatitis – Relief from itching, flaking, and redness
• Atopic dermatitis (Eczema) – As an adjunctive skin-soothing treatment
• Rosacea-prone skin – For calming flare-ups and reducing irritation
• Wound healing – Minor cuts, abrasions, and post-procedure skin care
• Fungal skin infections – Such as athlete’s foot or ringworm (supportive use)
• Sunburn and skin irritation – To soothe and reduce inflammation
• Skin overgrowth of Propionibacterium acnes and Staphylococcus epidermidis
• Post-acne scar care and redness – As a skin-calming and rebalancing agent
• Adjuvant in skin rejuvenation therapies – Including after laser, dermabrasion, or peeling

Adults & Adolescents (≥12 years):

• Topical Spray/Gel/Cream: Apply a thin layer 1–3 times daily to affected skin, depending on severity.
• For acne/rosacea: Use twice daily on cleansed skin.
• Post-procedure: Apply every 6–8 hours during the first 24–48 hours as recommended.

Pediatric Use (2–12 years):

• Apply with caution once daily. Consult pediatrician before regular use.

Elderly:

• No specific dose adjustment needed. Monitor for dryness or irritation.

Special Groups:

• Renal/Hepatic impairment: Not systemically absorbed; no dosage change needed.
• Application Method: Clean skin before use. Avoid eyes and mucous membranes.
• Duration of Use: Short-term use (1–4 weeks) or as needed depending on indication.

This topical combination acts through synergistic antimicrobial, anti-inflammatory, and skin-calming properties. Tea tree oil (Melaleuca alternifolia) contains terpinen-4-ol, which disrupts microbial cell membranes, showing broad-spectrum antibacterial and antifungal action. Echinacea extracts modulate local immune responses, promoting macrophage activation and cytokine balance, enhancing skin barrier repair. Geothermal water, rich in trace minerals (selenium, zinc, silica), soothes irritation and supports epidermal regeneration. Together, they reduce skin inflammation, control microbial colonization, and promote healing.

This preparation is topical and minimally systemically absorbed, so pharmacokinetic data are limited:

• Absorption: Tea tree oil and Echinacea components penetrate the stratum corneum; systemic absorption is negligible.
• Distribution: Localized to skin and adnexal structures.
• Metabolism: Metabolized locally by skin enzymes; minor systemic exposure may be hepatic if absorbed.
• Excretion: Not significant systemically; no renal excretion relevance.
• Onset of Action: Within 12–48 hours for symptom relief (redness, itching).
• Peak Effect: After consistent use for 7–10 days.

• Pregnancy: No FDA category (herbal/dermaceutical); generally considered low risk for topical use. Avoid extensive application, especially on broken skin during pregnancy.
• Lactation: Safe when used topically on non-breast areas. Avoid nipple area to prevent infant ingestion.
• Caution: Use only under healthcare supervision in pregnant/lactating women. Data on high-dose or long-term use are limited.

• Primary Class: Dermatological Herbal Antimicrobial & Anti-inflammatory
• Sub-Class: Natural Skin Soothing Agent / Non-steroidal topical therapy

• Known hypersensitivity to tea tree oil, Echinacea, or geothermal minerals
• History of contact dermatitis or allergic skin reactions to essential oils or botanicals
• Open wounds or extensive broken skin (for concentrated formulations)

• Patch test required before first use due to potential allergic reactions
• Avoid eye and mucous membrane contact; can cause irritation
• Not for oral, vaginal, or rectal use
• Pediatric use under 2 years not recommended
• Photosensitivity may occur with tea tree oil in rare cases
• Discontinue use if rash, burning, or excessive peeling occurs
• Use with caution in patients with autoimmune conditions (Echinacea may stimulate immunity)

Common:

• Mild skin dryness
• Transient burning or tingling
• Skin redness

Less Common:

• Contact dermatitis
• Flaking or peeling skin
• Photosensitivity

Rare/Serious:

• Allergic skin reactions
• Urticaria or angioedema (very rare)
• Delayed hypersensitivity response

Side effects are typically dose-dependent and occur early in use; usually resolve on discontinuation.

• Topical corticosteroids: May reduce efficacy of tea tree oil's immune-modulating effects
• Other topical antimicrobials (e.g., clindamycin): Use with caution to avoid skin barrier disruption
• Immunosuppressants (oral/topical): Theoretical interaction with Echinacea due to immune stimulation
• Essential oils or herbal preparations: Increased risk of skin irritation or allergy

CYP450-related systemic drug interactions not applicable due to minimal absorption.

• Increasing use in integrative dermatology and natural acne treatment protocols
• Recognized in herbal dermatologic practice for post-laser care and inflammatory skin conditions
• Dermatologists recommend patch testing before long-term use due to essential oil sensitization risk
• Several cosmetic dermatology consensus guidelines now include geothermal water as a skin barrier repair agent

• Temperature: Store at 15°C to 25°C (59°F to 77°F)
• Protect from light and heat
• Do not freeze
• Shake well before use (if suspension or emulsion form)
• Shelf life: Check label; typically 24 months after manufacturing
• Close cap tightly after each use to prevent oxidation of essential oils