Salicylic Acid + Lactic Acid

• Acne Vulgaris: Treatment of mild to moderate acne by exfoliating skin and preventing clogged pores.
• Keratolytic Agent: Management of hyperkeratotic skin disorders, including:
• Mild plaque psoriasis
• Ichthyosis
• Seborrheic keratosis
• Calluses and corns
• Wart Removal: Treatment of common and plantar warts.
• Hyperpigmentation (Off-label): Mild melasma and uneven skin tone improvement.
• Dandruff and Seborrheic Dermatitis (Off-label): Reduction of scalp scaling.

• Adults and Adolescents (12 years and older):
  Apply a thin layer once or twice daily to clean, dry skin over affected areas. Avoid eyes, mucous membranes, and broken skin.
• Pediatrics (<12 years):
  Use with caution; only under medical supervision.
• Elderly:
  Use usual adult dose, monitor for skin sensitivity.
• Special Populations:
  No specific adjustments for renal or hepatic impairment for topical use.
• Duration:
  Continued use for 4 to 12 weeks or as advised by a healthcare provider.
• Route:
  Topical application as cream, gel, lotion, or solution.

Salicylic acid is a beta-hydroxy acid that acts by softening keratin, loosening and promoting the shedding of the outer layer of dead skin cells (stratum corneum), thereby preventing clogged pores and promoting exfoliation. It also exhibits anti-inflammatory properties. Lactic acid, an alpha-hydroxy acid, gently exfoliates by disrupting bonds between skin cells and provides moisturizing effects, improving skin hydration and pH balance. Together, they accelerate skin renewal and reduce hyperkeratosis, improving texture and clarity.

• Absorption: Minimal systemic absorption when applied topically; absorption may increase on damaged or large skin areas.
• Distribution: Limited to local skin application site.
• Metabolism: Systemic salicylic acid is metabolized primarily by the liver; lactic acid is metabolized via normal endogenous pathways.
• Excretion: Systemically absorbed salicylate is excreted via the kidneys.
• Onset of action: Skin exfoliation effects usually seen within days to weeks of consistent use.

• Pregnancy:
  FDA Pregnancy Category C. Topical use during pregnancy is generally considered safe if used sparingly and on limited areas. Avoid excessive or large-area application.
• Lactation:
  Minimal systemic absorption suggests low risk during breastfeeding, but avoid applying near the breast area to prevent infant exposure.

• Primary: Keratolytic agent
• Subclass: Combination of Beta-Hydroxy Acid (Salicylic Acid) and Alpha-Hydroxy Acid (Lactic Acid)

• Hypersensitivity to salicylic acid, lactic acid, or any component of the formulation
• Application on inflamed, infected, or broken skin
• Use in children under 2 years of age
• Known aspirin or salicylate allergy

• Avoid contact with eyes, mucous membranes, and damaged skin.
• May cause skin irritation, dryness, or burning sensation; discontinue if severe irritation occurs.
• Use cautiously in patients with sensitive or dry skin.
• Overuse on large skin areas can lead to systemic salicylate toxicity.
• Avoid occlusive dressings unless advised by a healthcare provider.
• Monitor elderly patients for skin tolerance.

• Common:
• Local irritation (redness, dryness, peeling)
• Mild burning or stinging sensation
• Rare but serious:
• Allergic contact dermatitis
• Chemical burns (especially with improper use)
• Systemic salicylate toxicity in cases of extensive use

• Minimal systemic interactions expected due to topical use.
• Concurrent use with other topical keratolytics or exfoliants may increase irritation.
• Use with caution alongside photosensitizing agents, as exfoliation increases sun sensitivity.
• Avoid combination with harsh soaps or alcohol-based products to reduce irritation risk.

• Updated dermatological guidelines emphasize combined use of alpha- and beta-hydroxy acids for improved efficacy in acne and keratotic conditions.
• Warnings about risk of systemic toxicity in young children have been reinforced.
• New formulations aim to balance efficacy with improved skin tolerability.

• Store at 20°C to 25°C (68°F to 77°F).
• Protect from light and moisture.
• Keep container tightly closed.
• Do not freeze.
• Store in a dry place, away from excessive heat and humidity.
• Shake well before use if indicated.