Oxybuprocaine Hydrochloride

• Topical ocular anesthesia for diagnostic and minor surgical procedures, including:
• Tonometry
• Gonioscopy
• Foreign body removal from the eye
• Minor ocular surgeries and laser treatments
• Short-term pain relief for corneal abrasions or superficial eye injuries during procedures
• Pre-procedural anesthesia prior to ophthalmic examinations or interventions

• Route: Topical ocular (eye drops)
• Adults and Children: Instill 1–2 drops into the conjunctival sac of the affected eye(s) as needed for anesthesia.
• Onset: Approximately 30 seconds.
• Duration: About 10–20 minutes per dose.
• Frequency: Repeat doses may be applied every 10–15 minutes if necessary, but avoid excessive or prolonged use.
• Use under medical supervision only.
• Not intended for prolonged self-administration.

Oxybuprocaine hydrochloride is a topical ester-type local anesthetic. It works by reversibly blocking voltage-gated sodium channels on nerve cell membranes, preventing sodium influx and inhibiting the initiation and conduction of nerve impulses. This blockade results in loss of sensation in the ocular surface tissues, providing local anesthesia during eye procedures.

• Absorption: Minimal systemic absorption following topical ocular application.
• Distribution: Limited to local ocular tissues.
• Metabolism: Rapid hydrolysis by plasma esterases to inactive metabolites.
• Elimination: Metabolites primarily excreted renally.
• Onset of action: Within 30 seconds.
• Duration: 10–20 minutes.

• Pregnancy: No well-controlled human studies; use only if clearly needed.
• Lactation: Minimal systemic absorption; unlikely to affect breastfed infants but use with caution.

• Local anesthetic (ocular)
• Ester-type anesthetic

• Known hypersensitivity to oxybuprocaine or other ester-type local anesthetics
• Allergy to para-aminobenzoic acid (PABA) derivatives
• Corneal infections or severe ocular inflammation
• Use without medical supervision in children

• Avoid prolonged or excessive use to prevent corneal toxicity.
• May cause corneal epithelial damage if used repeatedly or long-term.
• Use only under professional supervision.
• Avoid contamination of the dropper tip to prevent infections.
• Discontinue if signs of hypersensitivity or ocular irritation occur.

• Common: Mild transient burning, stinging, or blurred vision.
• Less common: Eye redness, tearing, irritation.
• Rare: Corneal damage, allergic reactions, anaphylaxis.

• No significant systemic interactions expected.
• Caution when used concurrently with other topical ocular medications to avoid irritation.

• No recent changes to indications or dosing.
• Emphasis on limiting use to procedural anesthesia to avoid corneal toxicity.
• Reinforced warnings against self-administration and prolonged use.

• Store at 20°C to 25°C (68°F to 77°F).
• Protect from light and moisture.
• Keep the container tightly closed.
• Do not freeze.
• Discard after expiration or if contamination is suspected.