Immortelle + Sensiva + Citrofol & Others

Allopathic
Indications

These ingredients are primarily used in cosmetic and skincare products for:

  • Improving skin hydration and barrier function
  • Providing antioxidant and anti-inflammatory effects
  • Gentle cleansing and skin conditioning
  • Enhancing skin repair and soothing irritation
  • Delivering natural fragrance and refreshing properties

Common product types include facial creams, serums, cleansers, body lotions, and shampoos.

Dosage & Administration
  • Applied topically as part of formulated cosmetic or personal care products.
  • Concentrations vary by formulation, commonly:
    • Immortelle extract: 0.1% to 2%
    • Sensiva (mild surfactants/conditioners): 0.5% to 5%
    • Citrofol (citrus-derived actives/fragrance): usually below 1%
  • Frequency depends on product type—typically once or twice daily for leave-on products; as needed for wash-off products.
  • No systemic dosing or adjustments necessary.
Mechanism of Action (MOA)
  • Immortelle (Helichrysum italicum extract): Contains polyphenols and flavonoids that neutralize free radicals, reducing oxidative damage. It also modulates inflammatory cytokines, promoting skin healing and reducing redness.
  • Sensiva: Acts as mild surfactants and skin conditioning agents that cleanse the skin gently without disrupting the natural barrier, improving moisture retention and reducing irritation risk.
  • Citrofol: Provides natural citrus bioactives and fragrance, contributing antioxidant effects and enhancing skin freshness.
Pharmacokinetics
  • Minimal or no systemic absorption after topical application.
  • Effects localized to the skin surface and superficial layers.
  • Metabolized locally by skin enzymes or naturally degraded.
  • No significant systemic exposure.
Pregnancy Category & Lactation
  • These ingredients are cosmetic and not classified under pharmaceutical pregnancy categories.
  • Generally considered safe for topical use during pregnancy and lactation.
  • Caution advised for concentrated essential oils or extracts; consult healthcare provider if unsure.
Therapeutic Class
  • Cosmetic skin care actives and surfactants
  • Antioxidants and skin conditioning agents
Contraindications
  • Hypersensitivity or allergy to any ingredient in the product formulation.
  • Avoid use on broken, damaged, or severely irritated skin unless directed by a healthcare professional.
Warnings & Precautions
  • Conduct patch testing before first use to identify possible allergic reactions.
  • Avoid contact with eyes and mucous membranes.
  • Discontinue use if skin irritation or rash develops.
  • Store products as recommended to maintain ingredient stability.
Side Effects
  • Generally well tolerated in recommended cosmetic concentrations.
  • Possible mild skin irritation, redness, or allergic dermatitis in sensitive individuals.
  • Rare photosensitivity with some botanical extracts.
Drug Interactions
  • No known systemic drug interactions.
  • Concurrent use with other strong topical actives should be supervised to prevent irritation.
Recent Updates or Guidelines
  • Growing use of natural botanical extracts like Immortelle in anti-aging and reparative skincare.
  • Sensiva surfactants increasingly favored for mildness and environmental sustainability.
  • Citrofol components evaluated for allergenicity with ongoing formulation optimization.
Storage Conditions
  • Store at 20°C to 25°C (68°F to 77°F).
  • Protect from heat, moisture, and direct sunlight.
  • Keep containers tightly sealed to prevent contamination and preserve efficacy.