Eucalyptol + Menthol + Thymol

• Oral Hygiene: Adjunctive treatment for reducing dental plaque and gingivitis.
• Mouthwash for Halitosis: Helps control bad breath by reducing oral microbial load.
• Mild Oral Inflammation: Relief of minor oral mucosal irritations.
• Prevention of Plaque Formation: Used in daily oral care to inhibit bacterial colonization.
• Off-label Uses: Temporary symptomatic relief in minor mouth ulcers and stomatitis.

• Form: Usually available as a mouthwash or oral rinse solution.
• Adults and Children >12 years: Use 10–20 mL as a mouth rinse, swish for 30 seconds to 1 minute, then spit out.
• Frequency: Twice daily, preferably after brushing teeth.
• Pediatrics <12 years: Use with caution; generally not recommended unless directed by a healthcare professional.
• Special populations (elderly, renal/hepatic impairment): No specific dose adjustments required due to topical use.
• Route: Oral rinse; do not swallow.
• Duration: Use regularly for oral hygiene; for therapeutic purposes, use as directed by a dental professional.

Eucalyptol, menthol, and thymol exert their therapeutic effects primarily through their antimicrobial and anti-inflammatory properties. These compounds disrupt bacterial cell membranes, inhibit bacterial enzymes, and reduce biofilm formation, thereby decreasing the bacterial load responsible for plaque and gingivitis. Additionally, menthol provides a local anesthetic and cooling effect by activating cold-sensitive TRPM8 receptors on oral mucosa, which relieves minor discomfort. Thymol contributes antiseptic effects by disrupting microbial cell walls. Collectively, these actions reduce oral inflammation and inhibit plaque development, promoting oral health.

• Absorption: Minimal systemic absorption when used as directed in oral rinse form.
• Distribution: Primarily localized to the oral mucosa and dental surfaces.
• Metabolism: If absorbed systemically, eucalyptol, menthol, and thymol undergo hepatic metabolism.
• Elimination: Metabolites are excreted mainly via the kidneys.
• Onset of action: Immediate antimicrobial and soothing effects locally upon use.

• Pregnancy: Limited systemic absorption suggests minimal risk when used as directed topically. Classified as Category C by the FDA due to lack of controlled human studies. Use only if clearly needed and after consulting a healthcare provider.
• Lactation: Considered safe during breastfeeding with topical use; systemic exposure is negligible. Avoid ingestion.

• Primary Class: Oral antiseptic agents
• Subclass: Essential oil-based antimicrobial oral rinses

• Known hypersensitivity or allergy to any component (e.g., menthol, eucalyptol, thymol).
• Open wounds or severe oral mucosal ulcerations unless directed by a healthcare professional.
• Children under 12 years of age, unless prescribed by a dentist or physician.

• Avoid swallowing to prevent systemic toxicity.
• Discontinue use if oral irritation or allergic reactions occur.
• Use with caution in patients with a history of hypersensitivity to essential oils.
• Keep out of reach of children to prevent accidental ingestion.
• Not a substitute for mechanical plaque removal (tooth brushing and flossing).
• Monitor for signs of mucosal irritation or allergic response, especially in sensitive individuals.

• Common: Mild oral irritation or burning sensation, transient altered taste.
• Rare/Serious: Allergic reactions including rash, swelling, or difficulty breathing.
• Prolonged use may cause mucosal dryness or irritation in sensitive users.

• No significant drug-drug or drug-food interactions are expected with topical oral use.
• Caution with concurrent use of other oral antiseptics or essential oil-containing products to avoid additive irritation.

• Current clinical guidelines support the use of essential oil-containing mouthwashes as effective adjuncts in plaque and gingivitis control.
• No recent significant changes in indications or safety warnings have been reported by regulatory agencies.
• Continued recommendation for use in adults and children over 12 years as part of comprehensive oral hygiene.

• Store at 20°C to 25°C (68°F to 77°F).
• Protect from direct sunlight and excessive heat.
• Keep container tightly closed.
• Avoid freezing.
• Keep out of reach of children.