Copper Peptide + Procapil + Niacinamide + Biotin + L-Arginine

Approved and Clinically Accepted Uses:

• Hair Loss Treatment (Androgenetic Alopecia):
  – Stimulates hair growth, increases follicular density, and reduces hair fall in men and women.
• Hair Strengthening and Nourishment:
  – Enhances scalp microcirculation and revitalizes hair roots.
• Scalp Rejuvenation:
  – Improves scalp health and reduces inflammation or oxidative stress on follicles.
• Nutritional Scalp Support:
  – Addresses deficiency-related hair thinning through essential amino acids and vitamins.
• Adjunct in Alopecia Therapy:
  – Supports medical or surgical treatment of alopecia by improving hair anchorage.

• Adults:
• Topical Application (Serum or Solution):
  – Apply 1–2 mL to the affected scalp area once or twice daily.
  – Gently massage with fingertips to aid absorption.
  – Do not rinse; allow the product to remain on the scalp.
• Duration:
• Minimum treatment period of 3 months recommended for visible results. Continued use supports long-term maintenance.
• Pediatrics:
• Not typically recommended under 18 years unless under specialist supervision.
• Elderly:
• Same adult dosing applies; evaluate scalp condition before use.
• Renal/Hepatic Impairment:
• No specific dose adjustment needed as systemic absorption is minimal.

• Copper Peptide: Acts as a growth modulator, stimulating follicular angiogenesis and activating extracellular matrix repair. It prolongs the anagen (growth) phase of hair follicles and reduces inflammation.
• Procapil: A synergistic blend of oleanolic acid, apigenin, and biotinyl-GHK that inhibits dihydrotestosterone (DHT) effects at the follicle and improves scalp microcirculation, promoting healthier hair anchoring.
• Niacinamide (Vitamin B3): Improves scalp circulation, enhances keratin synthesis, and reduces oxidative damage to follicles.
• Biotin (Vitamin B7): Plays a key role in keratin infrastructure and supports strong, thick hair growth.
• L-Arginine: A precursor to nitric oxide, it enhances local blood flow to the scalp, improving nutrient delivery to follicles and stimulating hair regeneration.

• Absorption:
  – Minimal systemic absorption due to topical use.
  – Active ingredients act locally on the scalp and follicular units.
• Distribution:
  – Localized to the applied area; limited systemic distribution.
• Metabolism:
  – Metabolized primarily in the skin layers; minimal hepatic involvement.
• Excretion:
  – Systemically absorbed components (if any) are eliminated via renal and hepatic pathways in trace amounts.
• Onset of Action:
  – Initial results may be seen after 4–6 weeks; optimal effects are observed after 12–16 weeks of consistent use.

• Pregnancy:
  – Not FDA-categorized due to topical and cosmetic nature. Caution advised. Avoid use unless prescribed during pregnancy.
• Lactation:
  – Safety in breastfeeding not well established; avoid applying on or near chest during nursing.
• Caution:
  – Use only under medical advice in pregnant or lactating individuals due to limited systemic safety data.

• Primary Class: Hair Growth Stimulator and Follicular Nutrient Therapy
• Subclass: Peptide-based topical anti-hair loss formulation with vascular, hormonal, and nutritional support agents

• Known hypersensitivity or allergy to any of the active components or formulation excipients
• Active scalp infections or severe dermatological conditions (e.g., psoriasis, eczema) at the site of application
• Open wounds or ulcerated scalp areas
• Concurrent use with incompatible topical treatments without professional supervision

• For external use only.
• Avoid contact with eyes, mucous membranes, or broken skin.
• Discontinue if scalp irritation, redness, or allergic reaction occurs.
• Perform a patch test before first-time use.
• Not intended to replace systemic hair loss treatment in advanced alopecia.
• Use with caution in patients with highly sensitive skin or known allergies to botanical extracts or peptides.
• Avoid excessive sun exposure on treated areas.

• Common (Local Reactions):
  – Mild itching, dryness, redness, burning sensation at application site
• Uncommon:
  – Scalp flaking or irritation, folliculitis
• Rare/Serious:
  – Allergic dermatitis, facial swelling, severe erythema (requires discontinuation)
• Timing:
  – Usually mild and self-limited; often occur within the first 1–2 weeks of initiation

• Topical Drug Interactions:
  – Concurrent use with corticosteroids, minoxidil, or retinoids may increase irritation risk
  – Apply other scalp treatments at different times of day to prevent overlap or dilution
• Systemic Drug Interactions:
  – None expected due to negligible systemic absorption
• Alcohol/Herbal Use:
  – No known interaction with alcohol or dietary supplements, but caution is advised if taking multiple skin/hair-related products

• Increasing clinical support for multi-agent peptide + botanical combinations in early-stage androgenetic alopecia
• Some dermatological societies now recognize Procapil and Copper Peptides as viable adjuncts in combination hair regimens
• Niacinamide and Biotin are widely acknowledged in dermatology guidelines as supportive agents in nutritional hair loss therapy
• New formulations emphasize peptide penetration enhancers and sustained-release delivery for improved outcomes

• Store at 20°C to 30°C (68°F to 86°F)
• Keep container tightly closed and upright in a dry place
• Protect from direct sunlight and heat
• Do not refrigerate or freeze unless specified by the manufacturer
• Use within the expiry period; discard if solution discolors or shows signs of degradation