Aqua, glycerin, PEG-40 hydrogenated castor oil, carbomer, Biolin, tocopheryl acetate

These ingredients are primarily used in topical cosmetic and dermatological formulations for:

• Hydration and Moisturization: Maintaining skin moisture and improving hydration.
• Emulsification and Texture Enhancement: Stabilizing and thickening formulations to improve consistency and application.
• Skin Barrier Support: Biolin, a prebiotic blend, promotes the growth of beneficial skin microbiota, supporting skin’s natural defense.
• Antioxidant Protection: Tocopheryl acetate provides antioxidant effects that protect skin cells from oxidative damage.

They are commonly found in moisturizers, serums, lotions, and creams, suitable for dry, sensitive, or compromised skin, and supportive in mild eczema or barrier dysfunction.

• Topical Use: Applied externally according to product instructions, typically once or twice daily.
• All Ages: Generally safe for pediatric and elderly populations; avoid eye contact.
• Special Populations: No dose adjustments needed; formulation-dependent.

• Aqua (Water): Acts as a solvent and vehicle for other ingredients, facilitating hydration.
• Glycerin: A humectant that attracts and retains water in the stratum corneum, improving skin softness and hydration.
• PEG-40 Hydrogenated Castor Oil: A non-ionic surfactant and emulsifier that disperses oils in water, stabilizing formulations and enhancing texture.
• Carbomer: A polymer that thickens and stabilizes gels and creams by forming a viscous matrix.
• Biolin: Prebiotic blend that fosters beneficial skin microbiota, reinforcing skin’s barrier and immune function.
• Tocopheryl Acetate: A stable form of Vitamin E that penetrates skin cells and neutralizes free radicals, providing antioxidant protection.

• Absorption: Topically applied; glycerin and tocopheryl acetate penetrate the epidermis to exert effects; PEG-40 and carbomer largely remain on skin surface.
• Metabolism & Excretion: Minimal systemic absorption; metabolites processed locally with negligible systemic exposure.

• Pregnancy: Safe for topical use during pregnancy; no known systemic effects.
• Lactation: Safe for topical use; minimal absorption limits infant exposure.
• Precaution: Avoid application on broken skin unless specifically formulated.

• Primary Class: Cosmetic and dermatological excipients.
• Subclass:
• Humectant (Glycerin)
• Emulsifier/Surfactant (PEG-40 Hydrogenated Castor Oil)
• Viscosity Enhancer (Carbomer)
• Prebiotic Agent (Biolin)
• Antioxidant (Tocopheryl Acetate)

• Hypersensitivity to any of the components.
• Avoid use on severely damaged or infected skin unless directed by a healthcare professional.

• For external use only.
• Avoid eye contact; rinse thoroughly if contact occurs.
• Discontinue use if irritation or allergic reaction develops.
• Patch testing recommended for sensitive skin.

• Common: Minimal; possible mild irritation or redness in sensitive individuals.
• Rare: Allergic contact dermatitis, especially if preservatives are present.

• No known drug-drug or drug-food interactions.
• Compatible with most topical medications and cosmetic products.

• Growing emphasis on prebiotic ingredients like Biolin to support skin microbiome health.
• Tocopheryl acetate remains widely recommended for antioxidant protection and skin aging prevention.
• Formulations focus on non-irritating, hydrating ingredients such as glycerin and carbomer for sensitive skin.

• Store at 20°C to 25°C (68°F to 77°F) in a dry place.
• Protect from heat, direct sunlight, and freezing.
• Keep containers tightly closed to prevent contamination.
• Follow specific product instructions if part of compounded formulations.