Aluminium Chloride + Melaleuca Alternifolia Oil + Geothermal water

• Primary Indication:
• Treatment of primary hyperhidrosis (excessive sweating), especially of the axillae, palms, and soles.
• Additional Indications:
• Adjunctive therapy for mild to moderate skin infections and inflammatory skin conditions, benefiting from the antimicrobial and anti-inflammatory properties of Melaleuca alternifolia (tea tree) oil.
• Skin soothing and conditioning for dry, irritated, or sensitive skin due to the mineral content of geothermal water.
• Off-label Uses:
• Management of minor skin irritations and prevention of body odor related to microbial overgrowth.

• Formulation: Topical application as solution, lotion, or spray.
• Adults:
• Apply a thin layer to clean, dry affected areas once daily, preferably at night for better antiperspirant efficacy.
• Avoid applying immediately after shaving or to broken skin to minimize irritation risk.
• Pediatrics: Use cautiously; consult a healthcare provider before use.
• Elderly: Same as adults; monitor for skin sensitivity.
• Special Populations: No dose adjustment necessary; avoid use on open wounds.
• Duration: Continued use until symptom control; maintenance as needed.
• Administration Notes: Wash hands thoroughly after application; avoid contact with eyes and mucous membranes.

• Aluminium Chloride acts by precipitating proteins in the sweat gland ducts, forming plugs that block sweat secretion and reduce perspiration.
• Melaleuca Alternifolia Oil exhibits broad-spectrum antimicrobial effects by disrupting microbial membranes and inhibits inflammatory mediators, helping reduce skin inflammation and infection.
• Geothermal Water contains minerals and trace elements that support skin barrier repair, hydration, and exert soothing, anti-inflammatory effects.

Together, these components reduce excessive sweating, control microbial growth, and improve skin condition.

• Absorption: Minimal systemic absorption due to topical use.
• Distribution: Localized action in the skin and sweat glands; negligible systemic distribution.
• Metabolism and Excretion: Any absorbed components undergo normal hepatic metabolism and renal elimination; systemic exposure is minimal.
• Onset of Action: Reduction in sweating may begin within days; antimicrobial and soothing effects develop with regular use.

• Pregnancy: Limited data available; topical use is generally considered low risk but should be used only if clearly needed.
• Lactation: No sufficient data; caution advised, especially if applied to breast area.

• Primary Classes:
• Antiperspirant (Aluminium Chloride)
• Topical antimicrobial and anti-inflammatory (Melaleuca alternifolia oil)
• Skin conditioning agent (Geothermal water)

• Known hypersensitivity to aluminium salts, tea tree oil, or formulation excipients.
• Application on broken, irritated, or infected skin.
• Severe dermatologic conditions aggravated by topical agents.

• Potential for local skin irritation, contact dermatitis, or allergic reactions.
• Avoid contact with eyes and mucous membranes.
• Discontinue if severe irritation or hypersensitivity develops.
• Use cautiously in patients with sensitive or atopic skin.
• Patch testing recommended before first use.

• Common: Mild skin irritation, dryness, itching, burning sensation.
• Less Common: Contact dermatitis or allergic rash.
• Rare: Severe hypersensitivity reactions.

• No significant systemic interactions expected due to minimal absorption.
• Concurrent topical irritants may increase skin irritation risk.

• Current dermatology guidelines recommend aluminium chloride as first-line topical therapy for hyperhidrosis.
• Incorporation of Melaleuca alternifolia oil for antimicrobial support is increasingly accepted with emphasis on low concentrations to minimize irritation.
• Patient education on proper application technique is critical to reduce adverse effects.

• Store at 20°C to 25°C (68°F to 77°F).
• Protect from direct sunlight, heat, and freezing.
• Keep container tightly closed.
• Avoid contamination and sharing applicators.