Allium cepa + Heparin + Allantoin

• Treatment and Prevention of Hypertrophic Scars and Keloids:
  Used topically to improve the appearance, texture, and redness of hypertrophic scars and keloids following surgery, trauma, or burns.
• Management of Post-Surgical Scars: Aids in softening, flattening, and reducing scar visibility.
• Cosmetic Scar Treatment: Helps in scar remodeling for improved skin aesthetics.
• Off-label: May be used for minor skin irritations or trauma scars, though primary evidence supports scar management.

• Route: Topical application (cream, gel, or ointment form).
• Adults and Pediatrics: Apply a thin layer 2–3 times daily on the affected scar area.
• Duration: Continue treatment for at least 8–12 weeks for optimal results; may extend up to 6 months based on scar maturation and clinical response.
• Special Considerations: Avoid application on open wounds or broken skin. Use under medical supervision if combined with other topical agents.

• Allium cepa (Onion Extract): Exhibits anti-inflammatory and antimicrobial properties; modulates fibroblast proliferation and collagen production, helping reduce excessive scar tissue formation.
• Heparin: Acts as an anticoagulant with anti-inflammatory effects; enhances local microcirculation, prevents fibrin accumulation, and promotes extracellular matrix remodeling, which contributes to scar softening and flattening.
• Allantoin: Promotes epithelialization and skin regeneration by stimulating cell proliferation and hydration; aids in soothing irritated skin and improving texture.

Together, these components synergistically improve scar appearance by reducing inflammation, modulating collagen synthesis, enhancing skin repair, and promoting scar remodeling.

• Absorption: Minimal systemic absorption due to topical administration; primarily acts locally at the application site.
• Distribution: Confined to the epidermal and dermal layers of skin.
• Metabolism & Excretion: Local metabolism in skin cells; negligible systemic exposure or elimination.

• Pregnancy: Topical use is generally considered safe; limited data but no known systemic risk. Use only if clearly needed.
• Lactation: Minimal systemic absorption suggests low risk during breastfeeding; avoid application on breast skin if nursing.

• Primary Class: Topical scar treatment agent
• Subclass: Combination of anti-inflammatory, anticoagulant, and skin-regenerating agents

• Known hypersensitivity to any of the components (Allium cepa, heparin, or allantoin).
• Open or infected wounds.
• History of allergic reactions to topical heparin preparations.

• Avoid contact with eyes and mucous membranes.
• Discontinue if irritation, rash, or allergic reaction occurs.
• Caution in patients with bleeding disorders or on systemic anticoagulants, though systemic absorption is minimal.
• Not for use on deep or extensive wounds without medical supervision.

• Common: Mild local skin irritation, redness, itching, or burning sensation at the application site.
• Rare: Allergic contact dermatitis or hypersensitivity reactions.
• Severity: Usually mild and transient; resolves upon discontinuation.

• Minimal systemic absorption leads to a very low potential for drug interactions.
• Avoid concurrent use with other topical products that may cause irritation unless supervised by a healthcare provider.

• Current dermatologic guidelines support the use of Allium cepa-containing topical products combined with agents like heparin and allantoin as safe and effective non-invasive options for scar management.
• Emerging evidence highlights the importance of early intervention in scar treatment to optimize outcomes.

• Store at 20°C to 25°C (68°F to 77°F).
• Protect from direct sunlight and moisture.
• Keep container tightly closed when not in use.
• Do not freeze.
• Store out of reach of children.