Rashcure

Approved Indications:

• Wound Healing: Treatment and support of healing in minor wounds, cuts, abrasions, burns, and skin ulcers.
• Skin and Mucous Membrane Disorders: Used for dryness, irritation, and inflammation of the skin and mucous membranes.
• Topical Use in Dermatology: For conditions such as diaper rash, eczema, and dermatitis.
• Postoperative Care: To promote healing of surgical wounds.
• Nasal and Ear Mucosa: Moisturizing and promoting regeneration in conditions like nasal dryness or after nasal surgery.
• Hair and Scalp Care: Used to improve scalp health and support hair growth in some formulations.

Off-label or Clinically Accepted Uses:

• Supportive therapy in radiation dermatitis.
• Treatment of mouth ulcers and stomatitis.
• Use in combination with other agents for treatment of chronic wounds and ulcers.

Adults and Pediatrics:

• Topical Application: Apply a thin layer of ointment, cream, or lotion to the affected area 2–3 times daily.
• Nasal Drops/Spray: Instill as per product instructions, typically 1–2 drops or sprays per nostril 2–3 times daily.
• Eye Drops (in some formulations): Administer as prescribed, usually 1–2 drops several times daily.
• Parenteral (Intramuscular/Intravenous) Use: Administer doses vary depending on clinical need; commonly 250–1000 mg per day divided into 2–3 doses, under medical supervision.

Special Populations:

• Elderly: No specific dosage adjustments required; monitor for skin sensitivity.
• Renal/Hepatic Impairment: No dose adjustments necessary.
• Pregnant and Lactating Women: Topical use considered safe; systemic use only if clearly indicated.

Dexpanthenol is the alcohol analog of pantothenic acid (vitamin B5) and serves as a provitamin that is rapidly converted in the body to pantothenic acid. Pantothenic acid is an essential component of coenzyme A, which plays a critical role in cellular metabolism, including the synthesis and repair of fatty acids, lipids, and proteins. By enhancing cellular energy metabolism and promoting epithelial regeneration, dexpantenol accelerates wound healing, reduces inflammation, and improves skin hydration and barrier function.

• Absorption: Rapidly absorbed and converted to pantothenic acid after topical or parenteral administration.
• Distribution: Pantothenic acid is distributed throughout the body tissues, including skin and mucous membranes.
• Metabolism: Metabolized intracellularly to coenzyme A, which participates in numerous metabolic pathways.
• Half-life: Short plasma half-life of pantothenic acid (about 1 hour), but biological effects persist due to involvement in coenzyme A function.
• Excretion: Excreted primarily in urine as metabolites of pantothenic acid.

• Pregnancy: No known teratogenic or embryotoxic effects; topical use is considered safe. Systemic use should be limited to cases where benefits outweigh risks.
• Lactation: Topical use is safe. Limited data on systemic use during breastfeeding; caution advised.

• Primary Class: Vitamin derivative (Provitamin B5)
• Subclass: Skin and mucosal healing agent, moisturizer

• Known hypersensitivity to dexpantenol or any formulation excipients.
• Avoid use on infected wounds unless combined with appropriate antimicrobial therapy.

• Use with caution on large open wounds; monitor for signs of infection.
• Rare allergic contact dermatitis has been reported.
• Avoid application to deep or puncture wounds without medical supervision.
• In case of hypersensitivity reactions, discontinue use immediately.
• For parenteral use, monitor for injection site reactions.

Common:

• Mild local irritation or burning sensation at the application site.
• Transient redness or itching.

Rare/Serious:

• Allergic contact dermatitis.
• Hypersensitivity reactions (rash, swelling).
• Injection site pain or inflammation (parenteral use).

• No significant drug interactions reported with topical or systemic use.
• No known interactions with food or alcohol.
• May be used safely alongside other topical agents, but avoid mixing with strong irritants.

• Updated wound care protocols emphasize use of dexpantenol-containing preparations to accelerate epithelialization and reduce healing time.
• Recognized as a safe and effective adjunct in management of radiation-induced dermatitis.
• Increasing use in combination therapies for chronic wound management supported by clinical guidelines.

• Store at controlled room temperature between 20°C and 25°C (68°F to 77°F).
• Protect from light and moisture.
• Keep ointments and creams tightly closed when not in use.
• Do not freeze.
• Keep out of reach of children.