N-Vit

Vitabion is indicated where a deficiency of the relevant B vitamins exists and is used for the treatment of various neurological and musculoskeletal disorders. The combination of these vitamins plays a crucial role in supporting nerve health, energy metabolism, and overall well-being.

1. Peripheral and Polyneuropathies

• Polyneuropathy of any origin, including:
• Alcoholic neuropathy
• Toxic neuropathy
• Diabetic neuropathy

2. Neural Disorders

• Neuritis (inflammation of nerves)
• Neuralgia (nerve pain)
• Intercostal neuralgia
• Trigeminal neuralgia
• Post-herpetic neuralgia associated with Herpes Zoster

3. Musculoskeletal Syndromes

• Cervical syndrome
• Shoulder-arm syndrome
• Lumbago (lower back pain)
• Sciatica
• Myalgia (muscle pain)

4. Supportive Therapy

• Facial paresis (partial facial paralysis)

রেজিস্টার্ড চিকিৎসকের নির্দেশনা অনুযায়ী ঔষধ সেবন করুন।

Adults

• Typical Dose: 1–2 tablets daily, or as directed by a physician.
• Tablets are usually taken orally after meals to improve absorption and minimize gastrointestinal discomfort.
• In some cases, the dose may be divided into two separate doses during the day.

Children

• Recommended Dose: Half to one tablet daily, depending on age and clinical condition, under medical supervision.
• Dose should be adjusted according to the child’s weight, vitamin deficiency severity, and response to therapy.

Elderly

• No specific adjustment is usually required.
• Monitor for tolerance, especially in patients with gastrointestinal sensitivity or chronic illnesses.

Special Populations

• Renal Impairment: Generally safe; no standard dose adjustment required.
• Hepatic Impairment: Use with caution in severe liver disease; monitor for adverse effects.
• Stress or Severe Deficiency: In acute or severe deficiency states, the physician may recommend higher doses temporarily.

Administration Tips

• Take after meals to enhance absorption.
• Swallow tablets whole with water; do not crush or chew.
• Maintain a regular dosing schedule for optimal effectiveness.
• For long-term therapy, periodic evaluation of vitamin levels may be recommended.

রেজিস্টার্ড চিকিৎসকের নির্দেশনা অনুযায়ী ঔষধ সেবন করুন।

Thiamine is phospho‑activated to TPP, crucial for energy metabolism and neuronal function. Pyridoxine becomes PLP, supporting amino acid metabolism, neurotransmitter synthesis, erythropoiesis, and homocysteine clearance. Cobalamin forms methyl‑ and adenosylcobalamin, essential for DNA synthesis, myelin stability, methylation processes, and neurologic health. Together, they maintain metabolic, hematologic, and neurologic integrity.

• Absorption:
  B₁/B₆ via intestinal transport; B₁₂ requires intrinsic factor in terminal ileum (passive absorption at high oral doses)
• Distribution:
  B₁₂ stored in liver; B₁/B₆ circulate freely and are quickly depleted
• Metabolism:
  B₁/B₆ converted to TPP and PLP; B₁₂ transformed into active cobalamin forms
• Excretion:
  Excess eliminated through urine; B₁₂ partly conserved via enterohepatic cycling
• Half‑Life:
  B₁: ~1–2 weeks
  B₆: ~15–20 days
  B₁₂: Days to weeks

• Pregnancy:
  Safe at RDA levels and important for fetal development. High-dose usage requires medical oversight.
• Breastfeeding:
  Vitamins are excreted into breast milk; supplementation contributes to infant nutrition.
• Cautions:
  High-dose pyridoxine (>100 mg/day) requires monitoring for neurologic effects.

• Primary Class: Water‑soluble vitamins
• Subclass: B‑complex essential nutrients
• Pharmacologic Category: Cofactor precursors and hematinic agents

• Hypersensitivity to B₁, B₆, or B₁₂
• Sensory neuropathy with high-dose B₆
• Unexplained seizure worsening with pyridoxine

• Anaphylaxis Risk: Rare with IV/IM thiamine
• Neuropathy: High-dose B₆ (>200 mg/day) may cause sensory neuropathy
• Seizure Risk: Monitor seizure control with pyridoxine therapy
• Hypokalemia: Possible with rapid B₁₂ therapy—monitor electrolytes

• Common: Mild GI upset (B₆), injection site discomfort, flushing (rare)
• Serious:
• IV thiamine: Rare anaphylaxis
• High-dose B₆: Peripheral sensory neuropathy
• High-dose B₁₂: Rare rash, dizziness
• Onset: Injection reactions may occur within minutes; neuropathy develops over weeks–months

• Levodopa: B₆ increases metabolism—may reduce motor effects
• Isoniazid: Depletes B₆—supplementation recommended
• Metformin/PPIs: May reduce B₁₂ absorption—monitor levels
• Phenytoin/Phenobarbital: Reduce B-complex levels—supplementation required
• Alcohol: Impairs all three vitamins’ absorption and increases excretion

• Migraine Management: High-dose riboflavin accepted as prophylaxis
• Malnutrition/Refeeding: Standard use of parenteral thiamine in high-risk patients
• B₆ Monitoring: Safety concern prompting alert on neuropathy risk over 200 mg/day

• Temperature: 15–25 °C (59–77 °F)
• Light: Protect (especially riboflavin) from UV
• Humidity: Store in dry, sealed container
• Handling: Shake liquid forms; store injectable vials upright, inspect before use
• Protection: Keep out of children’s reach; no refrigeration required unless specified