Mederma (Skin care for scars)

• Wound Healing:
  Used topically to promote healing of minor wounds, cuts, abrasions, and burns.
• Skin Regeneration:
  Indicated for skin irritation, inflammation, and dryness to aid in restoring damaged skin.
• Ulcer Care:
  Supports healing in chronic skin ulcers, including diabetic foot ulcers and pressure sores.
• Post-Surgical Care:
  Applied to enhance epithelialization and prevent infection in surgical wounds.
• Dermatitis and Minor Skin Lesions:
  Used adjunctively to soothe and repair irritated or inflamed skin.

• Adults and Pediatrics:
  Apply a thin layer topically to the affected area 2 to 3 times daily or as prescribed by the physician.
• Duration:
  Continue application until complete healing is observed, typically 7 to 14 days depending on wound severity.
• Special Precautions:
  Avoid application on deep puncture wounds, serious burns, or infected areas unless directed by a healthcare professional.

Cepalin is a standardized extract of Aloe vera containing polysaccharides, glycoproteins, and enzymes that promote wound healing by enhancing fibroblast proliferation and collagen synthesis. It exerts anti-inflammatory and moisturizing effects that reduce tissue edema and stimulate epithelial cell regeneration. Allantoin acts as a keratolytic agent that softens keratin, promotes cell proliferation, and accelerates desquamation. Together, they synergistically enhance tissue repair, reduce inflammation, and improve skin hydration, facilitating faster wound closure and skin restoration.

• Absorption:
  Minimal systemic absorption due to topical application; primarily acts locally at the site of application.
• Distribution:
  Localized effect on epidermis and dermis.
• Metabolism & Elimination:
  Not systemically metabolized or eliminated; components are broken down and cleared locally by skin cells.
• Onset:
  Symptomatic improvement and healing support begin within days of regular application.

• Pregnancy:
  Considered safe for topical use during pregnancy due to minimal systemic absorption.
• Lactation:
  Safe during breastfeeding when used topically; no known adverse effects on infants.
• Note:
  Data on systemic exposure are limited; use with caution if large skin areas are treated extensively.

• Topical wound healing agent
• Skin protectant and regenerative agent

• Known hypersensitivity or allergy to Aloe vera, allantoin, or any formulation excipients.
• Open deep wounds, severe burns, or infected skin lesions unless prescribed by a healthcare provider.

• Avoid contact with eyes and mucous membranes.
• Discontinue use if local irritation, rash, or hypersensitivity reaction occurs.
• Use cautiously in patients with sensitive skin or history of allergic dermatitis.
• Not intended for use on large body surface areas or systemic infections.

Common:

• Mild local irritation or burning sensation.
• Transient redness or itching at the application site.

Rare:

• Allergic contact dermatitis.
• Hypersensitivity reactions in susceptible individuals.

• No known significant drug-drug or drug-food interactions due to topical route.
• Caution advised if used concurrently with other topical medications; separate application times to avoid chemical incompatibility.

• No recent significant changes in approved indications or safety warnings.
• Continued endorsement by dermatology guidelines for adjunctive wound and skin care.
• Increasing use in complementary and integrative medicine for chronic wound management.

• Store at 20°C to 25°C (68°F to 77°F).
• Protect from excessive heat and direct sunlight.
• Keep the tube/container tightly closed to prevent contamination.
• Avoid freezing.
• Keep out of reach of children.