Glamor

Approved Indications:

• Ophthalmic Use: Treatment and prevention of dry eyes and irritation.
• Eye Surgery Adjunct: Used as a protective lubricant and volume expander during cataract surgery, corneal transplantation, and other ocular surgeries.
• Artificial Tear Substitute: For symptomatic relief of ocular dryness caused by environmental factors, contact lens wear, or insufficient tear production.
• Corneal Protection: To protect the corneal epithelium from damage due to surgical trauma, laser procedures, or chemical exposure.

Off-label or Clinically Accepted Uses:

• Postoperative eye care to promote healing and comfort.
• Management of mild to moderate keratoconjunctivitis sicca.
• Supportive treatment for ocular surface disorders.

• Route: Topical ophthalmic solution (eye drops).
• Adults and Pediatrics:
• Instill 1-2 drops in the affected eye(s) as needed, typically 3 to 6 times daily.
• Frequency may be increased for symptomatic relief, but usually not exceeding 12 drops/day.
• Elderly: No dosage adjustment necessary; same regimen as adults.
• Special Populations: No specific adjustments needed for renal or hepatic impairment due to topical route and minimal systemic absorption.
• Administration Instructions:
• Wash hands before use.
• Avoid contact of dropper tip with eye or any surface to prevent contamination.
• Close eyes gently after instillation and do not blink excessively.
• Wait at least 5 minutes between administration of different eye drops.

Dextran is a high molecular weight polysaccharide that acts as a lubricant and volume expander in the tear film, enhancing ocular surface hydration and protecting the corneal epithelium from mechanical and desiccation stress. Hypromellose (hydroxypropyl methylcellulose) is a viscous cellulose derivative that increases tear film viscosity and stabilizes the ocular surface by retaining moisture, reducing evaporation, and providing sustained lubrication. Together, these agents mimic natural tears and promote corneal epithelial healing and comfort.

• Absorption: Minimal systemic absorption following topical ocular administration.
• Distribution: Primarily remains on the ocular surface; forms a protective film over the cornea and conjunctiva.
• Metabolism: Not systemically metabolized; locally degraded and cleared by tear turnover.
• Elimination: Removed from the ocular surface by normal tear drainage and blinking.
• Onset of Action: Immediate symptomatic relief upon instillation.
• Duration: Effects typically last several hours depending on formulation viscosity and frequency of application.

• Pregnancy: No adequate controlled studies in pregnant women; topical use considered low risk due to minimal systemic absorption.
• Lactation: Minimal risk expected; unlikely to affect breastfeeding infant. Use with caution if large volumes applied or multiple daily doses.

• Primary Class: Ophthalmic lubricants and artificial tears.
• Subclass: Combination of polymeric tear substitute and volume expander.

• Known hypersensitivity to dextran, hypromellose, or any formulation excipients.
• Presence of active ocular infection (bacterial, viral, or fungal) unless specifically indicated.

• Avoid contamination of the dropper tip to prevent secondary ocular infections.
• If irritation, redness, or discomfort persists or worsens, discontinue use and consult a healthcare professional.
• Use with caution in patients with glaucoma as increased viscosity may affect intraocular pressure measurement.
• Not intended for use with contact lenses unless specified.
• In rare cases, hypersensitivity reactions may occur.

Common:

• Mild transient burning or stinging on instillation.
• Temporary blurred vision immediately after drop administration.
• Eye irritation or redness (rare).

Rare/Serious:

• Allergic conjunctivitis or hypersensitivity reactions.
• Secondary ocular infections due to contamination.

• No significant drug interactions reported.
• Wait at least 5–10 minutes between administration of other ophthalmic drugs to avoid dilution or washout.
• Use cautiously with other topical ophthalmic medications; separate dosing times as recommended.

• Recent ophthalmic guidelines emphasize use of combined lubricants with volume expanders for improved symptom control in dry eye disease.
• Enhanced formulations with dextran and hypromellose show better corneal protection during ocular surgery.
• Safety profile remains favorable with widespread clinical use and minimal adverse effects.

• Store at 20°C to 25°C (68°F to 77°F).
• Protect from freezing and excessive heat.
• Keep bottle tightly closed when not in use.
• Avoid exposure to direct sunlight.
• Use within the recommended period after opening (usually 30 days).
• Keep out of reach of children.