FlexiRun Plus

• Approved Indications:
• Dietary supplement formulation used primarily to support joint health, mobility, and function.
• Management of osteoarthritis symptoms, including joint pain, stiffness, and inflammation.
• Adjunctive support in rheumatoid arthritis for symptom relief and immune modulation.
• Important Off-Label (Clinically Accepted) Uses:
• Support in other inflammatory joint disorders and autoimmune conditions.
• Use in individuals with joint discomfort related to aging, overuse, or mild injury.

• Adults:
• Typical daily dose includes:
• Undenatured Type II Collagen: 40 mg orally once daily.
• Boswellia Serrata extract standardized to 65-70% boswellic acids: 100–300 mg orally two to three times daily.
• Pediatrics:
• Safety and efficacy not established; use not recommended.
• Elderly:
• Same as adult dosing; no specific adjustments generally needed.
• Special Populations:
• No dosage adjustment required in mild to moderate renal or hepatic impairment.
• Route of Administration:
• Oral capsules or tablets.
• Duration:
• Effects generally observed after 4 to 8 weeks; continuous use up to 6 months or longer depending on clinical response.

The combination of Undenatured Type II Collagen and Boswellia Serrata exerts synergistic effects to improve joint health. Undenatured Type II Collagen induces oral tolerance by modulating immune responses against endogenous collagen in joint cartilage, reducing autoimmune-driven inflammation and cartilage degradation. Boswellia Serrata contains boswellic acids that inhibit 5-lipoxygenase (5-LOX), a key enzyme in leukotriene synthesis, thereby reducing inflammatory mediators responsible for joint inflammation and pain. Together, they decrease inflammation, protect cartilage, and improve joint function.

• Undenatured Type II Collagen:
• Minimally absorbed intact; acts locally via immune modulation in gut-associated lymphoid tissue.
• Proteolytically degraded into peptides and amino acids; clinical effects manifest after weeks due to immunological tolerance.
• Boswellia Serrata Extract:
• Boswellic acids are absorbed variably with oral administration; peak plasma levels reached in 1 to 3 hours.
• Metabolized primarily in the liver; eliminated mainly via biliary excretion.
• Half-life varies depending on specific boswellic acids, generally several hours.

• Pregnancy:
• No adequate human studies; use only if clearly needed and benefits outweigh risks.
• Classified as pregnancy category N (not classified) by FDA.
• Lactation:
• Limited data available; caution advised.
• Breastfeeding women should consult healthcare providers before use.

• Nutritional supplement combination
• Immunomodulatory and anti-inflammatory agents for joint support

• Known hypersensitivity to Undenatured Type II Collagen, Boswellia Serrata, or any formulation excipients.
• Active gastrointestinal disorders or ulcers (due to Boswellia’s potential gastric irritation).
• Pregnancy and breastfeeding unless directed by a physician.

• Use with caution in patients with known allergies to chicken products or Boswellia.
• Boswellia may cause mild gastrointestinal upset; discontinue if severe symptoms occur.
• Not a substitute for prescription medications in autoimmune diseases or severe arthritis.
• Monitor for allergic reactions or unusual symptoms during therapy.
• Long-term safety beyond 6 months has limited data.

• Common:
• Mild gastrointestinal discomfort (nausea, abdominal pain, diarrhea).
• Occasional headache or dizziness.
• Rare:
• Allergic reactions such as rash, itching, or swelling.
• Possible mild elevations in liver enzymes (rare).
• Generally well tolerated at recommended doses.

• Boswellia Serrata:
• May interact with anticoagulants or antiplatelet drugs, increasing bleeding risk.
• Potential interaction with NSAIDs enhancing gastrointestinal side effects.
• Undenatured Type II Collagen:
• No significant drug interactions reported.
• No known food or alcohol interactions of clinical relevance.

• Increasing clinical evidence supports combined use for symptomatic relief in mild to moderate osteoarthritis.
• Recognized in some integrative medicine guidelines as adjunctive joint support.
• No FDA-approved therapeutic indication; marketed as a dietary supplement.
• Recent studies highlight favorable safety profile with immunomodulatory and anti-inflammatory benefits.

• Store in a cool, dry place between 20°C and 25°C (68°F to 77°F).
• Protect from moisture, heat, and direct sunlight.
• Keep container tightly closed when not in use.
• Keep out of reach of children.
• No refrigeration or special handling required.