Delentin

• Approved Indications:
• Treatment of intestinal nematode infections, including:
• Ascariasis (caused by Ascaris lumbricoides)
• Enterobiasis (Pinworm infection) (caused by Enterobius vermicularis)
• Trichostrongyliasis and other hookworm infections (e.g., Ancylostoma duodenale, Necator americanus)
• Effective against other intestinal roundworms sensitive to pyrantel.
• Off-label / Clinically Accepted Uses:
• Occasionally used for prophylaxis in endemic areas.
• Sometimes prescribed for mixed helminth infections where multiple intestinal nematodes are present.

• Adults and Children over 2 years:
• Single dose of 11 mg/kg (maximum 1 gram per dose) orally.
• Dose may be repeated after 2 weeks if reinfection or persistent infection is suspected.
• Children under 2 years:
• Use only if benefits outweigh risks; pediatric formulations and dosing should be guided by a physician.
• Administration:
• Oral tablets or suspension.
• Can be taken with or without food.
• For best effect, whole dose should be taken at once.
• Special Populations:
• No specific dosage adjustment for renal or hepatic impairment documented, but caution advised in severe cases.
• Elderly: Use standard dosing; monitor for tolerance.

Pyrantel pamoate is a depolarizing neuromuscular blocking agent that selectively stimulates nicotinic acetylcholine receptors on nematode muscle cells, causing persistent activation leading to spastic paralysis. The paralyzed worms lose their grip on the intestinal mucosa and are expelled by normal peristalsis, thereby eradicating the infection.

• Absorption: Minimal systemic absorption after oral administration; most remains in the gastrointestinal tract.
• Distribution: Limited systemic distribution due to poor absorption.
• Metabolism: Negligible systemic metabolism; primarily acts locally in the gut.
• Excretion: Mainly eliminated unchanged in feces; minimal renal excretion.
• Onset of action: Rapid, within hours of administration.

• Pregnancy: Classified as FDA Pregnancy Category C. Animal studies have not demonstrated teratogenic effects at therapeutic doses, but human data are limited; use only if clearly needed.
• Lactation: Pyrantel is excreted in breast milk in minimal amounts; generally considered compatible with breastfeeding, but caution advised.

• Anthelmintic
• Nicotinic acetylcholine receptor agonist / neuromuscular blocking agent (antinematodal agent)

• Known hypersensitivity to pyrantel pamoate or any component of the formulation.
• Intestinal obstruction or severe inflammatory bowel conditions.
• Caution in patients with liver disease or severe renal impairment.

• Not effective against all types of intestinal parasites (e.g., flatworms, tapeworms).
• Use caution in patients with hepatic or renal impairment.
• Monitor for signs of allergic reactions.
• Neurological symptoms (rare) such as dizziness or headache may occur.
• Avoid use in infants under 2 years unless prescribed by a physician.
• Maintain hygiene measures to prevent reinfection.

• Common:
• Gastrointestinal: nausea, vomiting, diarrhea, abdominal cramps, flatulence.
• Central nervous system: headache, dizziness, fatigue.
• Rare but Serious:
• Allergic reactions (rash, urticaria, angioedema).
• Neurological symptoms: dizziness, weakness (very rare).
• Side effects are generally mild, transient, and dose-dependent.

• No significant drug-drug interactions are well documented due to minimal systemic absorption.
• Concurrent use with piperazine is not recommended as it may antagonize the effects of pyrantel.
• No known significant interactions with food or alcohol.

• Maintained as a first-line agent in multiple international guidelines for treatment of pinworm and roundworm infections.
• Increasing emphasis on mass drug administration programs including pyrantel in endemic regions.
• No major recent safety warnings or dosage changes reported by FDA or WHO.

• Store at controlled room temperature: 20°C to 25°C (68°F to 77°F).
• Protect from moisture and light.
• Keep container tightly closed.
• Suspension formulations should be shaken well before use.
• Keep out of reach of children.