Activon

• Approved Indications:
• Symptomatic relief of musculoskeletal pain including:
• Strains, sprains, bruises
• Back pain and muscle aches
• Tendonitis and bursitis
• Arthritis (osteoarthritis and rheumatoid arthritis) pain relief
• Inflammation reduction in superficial soft tissue injuries
• Off-label Uses:
• Adjunct treatment in chronic joint conditions for symptomatic relief
• Minor sports injuries
• Relief of neuralgic pain associated with minor trauma

• Route: Topical application to affected area
• Adults:
• Apply a thin layer of cream/gel 3 to 4 times daily to clean, dry skin
• Gently rub until fully absorbed
• Maximum daily dose depends on product formulation; typically do not exceed 10–15 g/day
• Pediatrics:
• Use with caution in children under 12 years; usually not recommended without medical advice
• Elderly:
• No specific dosage adjustment; caution if skin integrity is compromised
• Special Populations:
• Avoid application on broken, damaged, or irritated skin
• Not recommended for use in patients with severe hepatic or renal impairment due to systemic absorption risk, though minimal

Diethylamine salicylate is a topical salicylate ester that exerts anti-inflammatory and analgesic effects through the local inhibition of cyclooxygenase enzymes (COX-1 and COX-2), leading to decreased synthesis of prostaglandins which mediate pain and inflammation. The diethylamine salt form enhances skin penetration, allowing the active salicylate to reach subcutaneous tissues and act locally to reduce inflammation, swelling, and pain without significant systemic effects.

• Absorption: Limited systemic absorption through intact skin; increased if applied over large areas or damaged skin
• Distribution: Primarily localized at site of application; negligible systemic distribution at therapeutic doses
• Metabolism: Systemic absorption, if any, undergoes hepatic metabolism similar to salicylates
• Elimination: Metabolites excreted primarily via urine
• Onset: Symptomatic relief usually within 30 minutes to 1 hour post-application
• Duration: Effects may last several hours; repeat application as directed

• Pregnancy:
• Use only if clearly needed and after risk-benefit assessment
• Limited data on topical use; systemic absorption is low but caution advised especially in the third trimester due to potential effects on fetal circulation
• Lactation:
• Probably safe due to minimal systemic absorption
• No known adverse effects on breastfed infants reported
• Avoid applying to breast area during breastfeeding

• Primary Class: Topical analgesic and anti-inflammatory agent
• Subclass: Salicylate ester topical preparation

• Known hypersensitivity to salicylates or diethylamine salicylate formulations
• Allergy to aspirin or other NSAIDs
• Open wounds, broken or irritated skin at application site
• Severe hepatic or renal impairment (relative contraindication due to potential systemic absorption)

• Avoid contact with eyes, mucous membranes, or broken skin
• Use cautiously in patients with asthma or aspirin-sensitive conditions due to potential cross-reactivity
• Risk of systemic salicylate toxicity is very low but increases with excessive application or large treated area
• Discontinue if rash, itching, or irritation develops
• Avoid use in children under 12 without medical advice
• Do not apply under occlusive dressings unless directed by a healthcare professional

• Common:
• Local skin irritation or redness
• Mild burning or stinging sensation at application site
• Rare/Serious:
• Allergic dermatitis or hypersensitivity reactions
• Photosensitivity reactions with prolonged use
• Systemic salicylate toxicity (very rare, usually due to misuse)

• Minimal systemic absorption reduces risk of systemic drug interactions
• Caution if used concomitantly with systemic salicylates or NSAIDs to avoid additive effects and toxicity
• Avoid simultaneous application with other topical products that may cause irritation

• Current clinical guidelines support topical salicylates as first-line options for mild to moderate musculoskeletal pain with a good safety profile
• Emphasis on patient education regarding proper use and avoidance of overuse to prevent toxicity
• New formulations improve skin penetration and patient tolerability

• Store at controlled room temperature: 20°C to 25°C (68°F to 77°F)
• Protect from excessive moisture and direct sunlight
• Keep container tightly closed when not in use
• Avoid freezing temperatures
• Keep out of reach of children